The correlation of metabolism between glucose and dopamine transporter in patients with Parkinson's disease
- VernacularTitle:帕金森病多巴胺转运体代谢和葡萄糖代谢相关性研究
- Author:
Tao FENG
;
Yongjun WANG
;
Linlong LU
;
Wei LI
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
dopamine transporter;
glucose
- From:
Chinese Journal of Practical Internal Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between glucose metabolism and dopamine transporter in patients with Parkinson's disease.Methods Eleven patients at stage 2~3 of PD and three patients with essential tremor were examined by 18F-FDG PET and 11C-CFT PET in two separate days within four weeks.The regional glucose binding and dopamine transporter binding were assessed with PET specific software in anterior putamen,posterior putamen,caudate nucleus,thalamus and occipital cortex.The tracer uptake rate between the region of interest and occipital cortex was analyzed as the main variables.Results The marked reduction of 18F-FDG uptake and 11C-CFT uptake was observed in posterior putamen in patients with PD.The reduction of tracers uptake in posterior putamen contralateral to onset side was more significant than the posterior putamen ipsilateral to onset side (P
