Change in ventricular repolarization among healthy young males exposed to high altitude
10.7644/j.issn.1674-9960.2014.04.006
- VernacularTitle:高原暴露健康青年人群心室肌复极变化研究
- Author:
Baida XU
;
Wei LU
;
Jie YU
;
Jun QIN
;
Jihang ZHANG
;
Shuangfei LI
;
Lan HUANG
- Publication Type:Journal Article
- Keywords:
ventricular repolarization;
high altitude;
QT interval;
QTc interval;
TpTe interval;
TpTec interval
- From:
Military Medical Sciences
2014;(4):259-261,280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change in ventricular repolarization at different altitudes and time courses among healthy young males .Methods A total of 143 healthy young men living on the plains were randomly selected as subjects.Their change in relative parameters of ventricular repolarization was measured by the same person at 500 m above sea level,24 hours their ascent to the plateau at an altitude of 3700 m was,after one week′s acclimatization on the 4400 m plateau and after 50 days acclimatization on the 4400 m plateau.Results Compared with 500 m,at 3700 m above sea level in 24 hours and after one week′s acclimatization on the 4400 m plateau,the heart rate(HR),systolic blood pressure(SBP), diastolic blood pressure(DBP), heart rate-corrected-QT (QTc)interval and heart rate-corrected T-peak to T-end (TpTec) on V3 lead were significantly increased(P<0.05).while oxygen saturation, QT interval,T-peak toT-end(TpTe)interval on V3 lead were significantly decreased ( P<0.05) .Compared with 500 m, oxygen saturation significantly decreased ( P<0.05),while SBP,DBP,QT interval,QTc interval,TpTe interval,TpTec interval did not change significantly (P>0.05) after 50 days acclimatization on the 4400 m plateau.Conclusion The ventricular repolarization duration of these young healthy men was significantly increased when they rapidly ascentded to high altitude .With prolonging residence at high alti-tude,the ventricular repolarization duration gradually returned to the level on the plains ,suggesting that the the ventricular repolarization duration will be restored to its level on the sea level by the adaptation and adjustment mechanism of the body .