Rosiglitazone reduces no-reflow area following reperfusion after AMI by inhibiting adhesion molecules in rats
- VernacularTitle:罗格列酮抑制粘附分子表达减轻大鼠急性心肌梗死再灌注后无再流
- Author:
Quan HE
;
Han LEI
;
Shu QIN
;
Kanghua MA
- Publication Type:Journal Article
- Keywords:
no-reflow phenomenon;
myocardial infarction;
rosiglitazone;
intercellular adhesion molecule-1;
P-selectin
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism by which rosiglitazone affects no-reflow following reperfusion after acute myocardial infarction(AMI).Methods Forty-five SD rats were randomly divided into sham-operated group,normal saline treated group and rosiglitazone treated group(at dose of 3 mg?kg-1?d-1,for 14 d),15 rats in each group.To establish no-reflow model,the rats of the latter two groups received coronary artery ligation for 3 h and reopening for 2 h.Then pathological staining for no-reflow area,chemical assay for MPO activity,immunohistochemistry and RT-PCR for protein and mRNA expressions of ICAM-1 and P-selectin in myocardium were performed.Results No-reflow area in rosiglitazone treated group was significantly reduced,compared with that in normal saline treated group(P
