Studies of the mechanism and inhibitory effect of aescine on SGC-7901 cells in vitro
- VernacularTitle:七叶皂苷体外抗SGC-7901细胞的作用及机制研究
- Author:
Zixia WU
;
Haijing WU
;
Li CAO
;
Xiaofei SUN
;
Zhijun MING
;
Xueguang ZHANG
- Publication Type:Journal Article
- Keywords:
Aescine;
apoptosis;
SGC-7901
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the mechanism and inhibi-tory effect of Aescine on SGC-7901 cells in vitro.Methods MTT method was used to detect SGC-7901 proliferation.Flow cytometer method was used to determine cell cycles.AnnexinⅤ-FITC apoptosis derection kit was used to detect apoptosis of cells.Western blot was employed to analyze the expression of Bcl-2.Results MTT result showed that Aescine could significantly inhibit the growth of SGC-7901.AnnexinⅤ-FITC apoptosis derection kit and Western blot results suggested that Aescine could induce the apoptosis of SGC-7901.Conclusions Aescine can inhibit the growth of SGC-7901 and induce the apoptosis of cells in vitro.
