Effects of chronic morphine treatment on contents of cAMP and cGMP in sympathetic ganglia of rats
- VernacularTitle:慢性吗啡处理对大鼠交感神经节cAMP、cGMP水平的影响
- Author:
Ping HE
;
Ning MO
;
Hongbo YU
- Publication Type:Journal Article
- Keywords:
morphine;
dependence;
tolerance;
withdrawal;
sympathetic ganglion;
cAMP;
cGMP
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of chronic morphine treatment on the contents of cAMP and cGMP in sympathetic ganglia,superior cervical ganglia(SCG) of rats.Methods The chronic morphine dependent model of rats was established by subcutaneous injection of morphine in gradually increasing doses for 5 days,the dependence and the tolerance of the model was estimated by naloxone precipitation test and 55℃ tail-flick trail test respectively.The contents of cAMP and cGMP in SCG were detected by means of 125I radioimmunoassay.Results ① Compared with control group,the content of cAMP in SCG of morphine-acute group rats was descended(P0.05;compared with morphine-acute,P0.05).Conclusion There was an up-regulation of cAMP in sympathetic ganglia of chronic morphine treated rats.
