Establishment of mice pruritus model induced by composite materials
- VernacularTitle:复合物质致小鼠瘙痒模型的建立
- Author:
Yuekui CHEN
;
Hui WANG
;
Qing LIANG
;
Ken CHEN
- Publication Type:Journal Article
- Keywords:
histamine;
dextran 40;
4-aminopyridine(4-AP);
pruritus;
model
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To research the influence of the animals pruritus model by used pruritus medium with histamine,dextran 40 or 4-aminopyridine(4-AP),and to establish a new pruritus model.Methods The orthogonal test was used to array the experiment.In the experiment different pruritus mediums were hypodermically injected for 0.1 ml in the depilated area,the scratching incubation period and scratching number in 30 minutes were counted after the injection.The best pruritus group was screened out by synthesis grading law.The injected skin area in each group was located out to be determined the histamine contents in it.Results The best model group was the combination of histamine and 4-aminopyridine.Compared with the blank group,the scratching number and scratching incubation period of other pruritus model groups in 30 minutes were of significant difference(P
