The research progress of hepatic stellate cell's apoptosis signaling pathway and the relative drugs
- VernacularTitle:肝星状细胞凋亡信号途径及其药物治疗的研究进展
- Author:
Yi ZHANG
;
Jie PING
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
liver fibrosis;
hepatic stellate cell;
apoptosis;
signaling pathways
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis can be caused by chronic liver injury arising from various etiological factors.The activation of the hepatic stellate cell(HSC) is the central event in liver fibrosis,the apoptosis of which was the initiating factor for the reversal process.The apoptosis of HSC is very complicated.The signaling pathways lack of enough research in regulating and controlling and activating HSC's apoptosis.The apoptosis pathways as known currently mainly include mitochondrial pathway,death receptor pathway and non-death receptor pathway.Based on these signaling pathways,selectively inducing cell death of activated HSCs is becoming the new antifibrotic treatment.This review focuses on the new progress of HSC's apoptosis signaling pathways,and summarizes the drugs that have the effect of inducing HSC apoptosis.
