The relationship of gap junction with the bystander effect in the HSV-TK/GCV treatment
- VernacularTitle:细胞缝隙连接与HSV-TK/GCV系统旁观者效应的关系
- Author:
Yan YANG
;
Liang TAO
- Publication Type:Journal Article
- Keywords:
connexin;
gap junction;
bystander effect;
HSV-TK/GCV system;
suicide gene therapy
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The bystander effect(BE) plays an important role in the gene therapy of cancer by the herpes thymidine kinase/ganciclovir(HSV-TK/GCV) system.It enhances the therapeutic efficacy of this system.Up to now,the exact underlying mechanism of the bystander effect remains unclear.A large body of evidence has indicated a close correlation of the connexin expression and gap junction in the targeted cells to the bystander effect.Here the publications concerning the relationship of gap junction with the bystander effect in the HSV-TK/GCV treatment have been reviewed.The possible cell death signals that can be transferred through gap junction to induce the bystander effect are also discussed.
