Progress in the study of phosphodiesterase-7 as a new target for anti-inflammatory and immune drug
- VernacularTitle:磷酸二酯酶7:一个新的抗炎免疫药物靶点研究进展
- Author:
Li ZHANG
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
cyclic AMP;
PDE7;
anti-inflammation and immunity;
PDE7 inhibitor
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Phosphodiesterases(PDEs) is the only protein enzyme family,which catalyze the hydrolysis of cyclic nucleotide second messages(cAMP and cGMP).PDEs regulate many physiologic and pathologic processes.Recent advance showed that PDE7 hydrolyze cAMP exclusively and is divided into PDE7A and PDE7B. PDE7 mainly express in immune and inflammatory cells.The selective inhibition of this family generates profound,functional effects and PDE7 has been used as a therapeutic target for diseases related with inflammation,such as chronic obstructive pulmonary disease(COPD),rheumatoid arthritis and Alzheimers disease(AD).
