Chiral selective effects of doxazosin and its enantiomers on cell proliferation in cultured vascular smooth muscle cells of the rat aorta
- VernacularTitle:多沙唑嗪光学异构体对大鼠主动脉平滑肌细胞增殖的选择性抑制作用
- Author:
Rongying WANG
;
Leiming REN
- Publication Type:Journal Article
- Keywords:
doxazosin;
enantiomer;
thoracic aorta;
vascular smooth muscle cell;
cell proliferation;
rat
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of racemic-doxazosin(rac-DOX),S-doxazosin(S-DOX) and R-doxazosin(R-DOX) on the proliferation of vascular smooth muscle cells(VSMCs) of the rat aorta.Methods VSMCs of the rat aorta were cultured,MTT assay was used to determine the cell proliferation and the morphological changes in VSMCs were analyzed using Giemsa's staining.Results The treatment with rac-DOX,S-DOX or R-DOX at 3~30 ?mol?L-1 for 96 h inhibited the proliferation of VSMCs significantly.However,the inhibitory effect of S-DOX on cell proliferation was more potent than that of R-DOX at the same concentration(P
