Effect of Removing Phlegm Softening and Removing Blood Stasis on Pulmonary Morphology and Hydoxyprolin of Pulmonary Fibrosis Rats
- VernacularTitle:祛痰散瘀软坚中药对肺纤维化大鼠肺组织病理形态学及HYP含量的影响
- Author:
Jun CHEN
;
Jun TANG
- Publication Type:Journal Article
- Keywords:
pulmonary fibrosis;
hydroxyprolin;
pathology;
Chinese herb
- From:
Journal of Zhejiang Chinese Medical University
2007;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[ Objective] To observe the effect of removing phlegm,softening and removing blood stasis on pulmonary morphology and hydoxyprolin of pulmonary fibrosis rats. [Methods]The experimental pulmonary fibrosis models were produced by injecting BLMA5.All animals were randomly divided into 5 groups which were control group, model group, Chinese herb high-dose group, Chinese herb low-dose group and prednisone group respectively, the drugs were given daily starting from the second day and the rats were killed on the 7th and 28th day. The shape of rats’ lung tissues was observed, the levels of hydroxyproline in lung tissues were measured. [Results] In model group, alveolitis increases(much inflammatory cell infiltration), pulmonary interstitial fibroblast increases. There is less pulmonary tissue inflammatory cell infiltration in drug-given groups than that in model group and so is fibroblast. Compared with the model group, the content of HYP of pulmonary tissues of the drug-given groups is remarkably decreased. [Conclusion] The Chinese herb of removing phlegm, softening and removing blood stasis can effectively inhibit the formation of pulmonary fibrosis caused by BLMA5.
