The Expression and Significance of IGF-1 and survivin in Reactive and Neoplastic Astrocytes
- VernacularTitle:IGF-1与survivin在反应性和肿瘤性星形胶质细胞中的表达及意义
- Author:
Chunqing ZHANG
;
Kun ZHAO
;
Danyang LI
- Publication Type:Journal Article
- Keywords:
Tissue chip;
Reactive astrocytes proliferation;
Astrocytomas;
IGF-1;
Bcl-2;
Survivin;
Ki-67
- From:
Journal of Medical Research
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the difference of IGF-1,Bcl-2,survivin and Ki-67 protein expression in reactive and neoplastic astrocytes and the significance of them.Methods Immunohistochemistry and tissue microarray techniques were used to determinate the expression of IGF-1,Bcl-2,survivin and Ki-67 protein in normal brain tissues, astrocytes proliferation,low-grade astrocytomas, and high-grade astrocytomas.Results The expression of IGF-1,Bcl-2,survivin and Ki-67 protein were all negative in control group.The positive expression rates of them in reactive astrocytes were 28.9%, 26.7%, 26.7% and 22.2%,respectvely; and in low-grade astrocytomas were 63.8%, 50.0%, 53.2%,70.2%; in high-grade astrocytomas were 88.9%, 79.2%, 88.1%,95.2%.IGF-1,Bcl-2,survivin and Ki-67 all had significant difference among the three experimental groups(P
