Effect of modified Didang Decoction on expression of TIMP-1 and PAI-1mRNA in glomerulosclerosis rats
- VernacularTitle:加减抵挡汤对肾小球硬化大鼠TIMP-1及PAI-1mRNA表达的影响
- Author:
Kefu CAI
;
Zengliang ZHANG
;
Xiaoling HUANG
- Publication Type:Journal Article
- Keywords:
Didang Decoction;
Glomerulosclerosis;
Plasminogen activator inhibito;
Tissue inhibitor of metalloproteinase
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the influence of Didang Decoction on glomerulosclerosis.Methods:The glomerulosclerosis model was established by uninephrectom and injection of adriamyci,and was treated by modif ied Didang Decoction and taken western medicine Losartan as the comparison group.To observe 24-hour urinary protein and kidney function of model group and each treatment group.Reverse transcriptase Polymerase Chain Reaction(RT-PCR) was used to determine the expression of TIMP-1 and PAI-1 in each group of rats kidney tissue.Results:Didang Decoction could decline elevated 24-hour urinary protein and improve kidney function,and decline the expression of TIMP-1 and PAI-1mRNA in glomerulosclerosis rats.Conclusion:Didang decoction could delay renal failure,it may be related to the down-regulated expression of TIMP-1 and PAI-1mRNA.
