The current status and prospect of early diagnosis for pancreatic carcinoma
- VernacularTitle:胰腺癌早期诊断研究的现状与展望
- Author:
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
pancreatic neoplasms;
early diagnosis;
turmor markers neoplasms;
oncogenes;
telomerase
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic carcinoma is one of the malignant tumors which is seriously harmful to the human health.Early diagnosis and operation of pancreatic carcinoma can significantly improve the survival rate and remarkably improve prognosis.Tumor markers have come into the research domain recent years such as CA19-9,CA50,CA242 and CA494.But none of tumor markers with sufficient sensitivity and specificity have been found to screen early panceatic carcinoma.Some cytokines including TGF,MIC-2,sICAM-1,sVCAM-1 and P-selectin play an important role in the diagnosis,therapy monitoring,and prognosis assessment of panceatic carcinoma.Being simple,convenient,economic,noninvasive and painless,B-ultrasound is the first choice of image diagnosis method for pancreatic carcinoma.Using CT,spiral CT,MR cholangio-pancreaticograph(MRCP) and endoscope ultrasound(EUS) alone has both advantages and disadvantages on diagnosing early pancreatic carcinoma.Detection of pancreatic juice,exfoliated cells,K-ras oncogene and telomerase activity by endoscopic retrograde cholangio-pancreaticography(ERCP) will be the major tendency to early diagnose the pancreatic carcinoma.The image method or serum marker alone may be unfit for the early clinical diagnosis of pancreatic carcinoma since their low sensitivity and specificity.Therefore,it should be done to seek the new tumor markers,and establish the united diagnosis model including image,exfoliated cells,oncogene,tumor suppressor gene and telomerase activity to improve the levels of pancreatic carcinoma diagnosis and treatment.
