Effects of clausenamide on hippocampus HO-1 and HO-2 expressions in diabetic rats
- VernacularTitle:黄皮酰胺对糖尿病大鼠海马HO-1和HO-2表达的影响
- Author:
Ruanling HOU
;
Bing LI
;
Linyu WEI
;
Yan MEI
;
Lin LIU
;
Jun LIN
- Publication Type:Journal Article
- Keywords:
diabetes mellitus;
clausenamide;
hippocampus;
heme oxygenase
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effects of clausenamide(Clau) on hippocampal heme oxygenase(HO-1 and HO-2) expressions in diabetic rats.Methods The diabetic rats model was produced by injecting streptozotocin (48 mg?kg-1). After 3 months,the HO-1 and HO-2 mRNA and protein expressions in hippocampus of diabetic rats were detected by RT-PCR and immunohistochemistry respectively.Results ① The results of RT-PCR showed that the protein expressions of HO-1 and HO-2 mRNA in hippocampus of diabetic group were higher than those of control group(P
