A preliminary study on the replication of continuity hyperuricemia rat model by administration and fed with hypoxanthine
- VernacularTitle:灌服与喂饲次黄嘌呤复制大鼠持续性高尿酸血症模型方法初探
- Author:
Li XU
;
Le SHI
- Publication Type:Journal Article
- Keywords:
hyperuricemia;
hypoxanthine;
uricase inhibitor;
animal model
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the fluctuation of uric acid in serum after replicating rat hyperuricemia model with hypoxanthine、uricase inhibitor combined,and to discuss the method of continuity hyperuricemia replication on rats. Method Hypoxanthine was administered via stomach or bait vessel,uricase inhibitor was injected subcutaneouslly,then the relative biochemical indicators of rats were inspected respectively at different periods of time after replicating the model. Results When hypoxanthine(50 g HX?kg-1bait vessel or 100 g HX?kg-1bait vessel) was administered via bait vessel,uricase inhibitor(200mg?kg-1) was injected subcutaneouslly,the uric acid in serum of different groups were much higher than control group(P
