The treatmengt effect of angiotensinⅡ receptor antagonist and angiotensin converting enzyme inhibitor on cardiac damage in rats with chronic renal failure
- VernacularTitle:缬沙坦及苯那普利对慢性肾衰竭大鼠心肌病变的治疗作用
- Author:
Daoyou ZHANG
;
Licai YANG
;
Feng WANG
;
Yanlang YANG
;
Fan ZHANG
;
Haihong XU
- Publication Type:Journal Article
- Keywords:
angiotensin converting enzyme inhibitor;
angiotensinⅡ receptor antagonist;
chronic renal failure;
left ventricular hypertrophy;
endothelin-1;
nitricoxide synthase;
transcription
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the protective effect of valsartan,benazepril and combination valsartan withbenazepril on cardiac damage in rats with chronic renal failure and explore the mechanism.Methods Forty Sprague Dawley male rats were selected,and were performed five-sixths nephrectomy to produce chronic renal failure model.Two weeks after the surgery,the rats were divided randomly into model group,valsartan group,benazepril group and both valsartan and benazepril group,and a sham group was established as control group.Systolic blood pressure,BUN and serum creatinine was measured at 10 week after operation,then all rats were killed to take the hearts for pathological histological observation.The transcription of endothelin-1(ET-1 )mRNA and nitricoxide synthase (eNOS-3) mRNA in myocardium was examined by hybridization in situ.Results Systolic pressure,heart weight,heart weight index,left ventricular weight mass(LVWM) and left ventricular weight mass index(LVWMI) in model group increased significantly at 10 week after operation. Systolic pressure,heart weight,heart weight index,LVWM and LVWMI decreased markedly in rats with five-sixths nephrectomy by valsartan and/or benazepril (P
