Progress in soluble A? oligomers in Alzheimer's disease and drugs targeting A? oligomers
- VernacularTitle:A?寡聚体与阿尔采末病及其靶点药物研究进展
- Author:
Ming LIU
;
Xianliang XIN
;
Ruiyu ZHOU
;
Xiaoguang DU
;
Meiyu GENG
- Publication Type:Journal Article
- Keywords:
A?;
A? oligomers;
Alzheimer's disease;
targets
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
A? plays a crucial role in Alzheimer's Disease and the soluble A? oligomers have been recognized as the emerging neurotoxins,which ultimately cause memory impairment and neuronal loss through different mechanisms.The development of novel drugs targeting A? oligomers indicates new and promising therapy approaches for AD.The pathological roles as the proximal toxins in AD and the compounds,targeting soluble A? oligomers,which are currently in preclinical and early clinical development,are reviewed.
