Progress in the development of early-onset antidepressants
- VernacularTitle:快速起效抗抑郁药物的研究进展
- Author:
Rui XUE
;
Youzhi ZHANG
;
Libo ZOU
- Publication Type:Journal Article
- Keywords:
antidepressant;
onset of action;
5-HT1Aantagonist;
5-HT2Aantagonist;
?2 antagonist;
dual/triple reuptake inhibitors
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Existing antidepressants exhibit delayed onset of action,which can decrease the compliance of the patients and enhance the risk of suicide.How to produce early-onset antidepressants with higher efficacy and lower adverse reactions has become a crucial point in the research of antidepressants.It has been demonstrated that selective 5-HT1Aantagonist,?2 antagonist and 5-HT2Aantagonist can accelerate the response of classic antidepressants.Furthermore,5-HT/NE dual reuptake inhibitor and 5-HT/NE/DA triple reuptake inhibitor can also produce early onset of action.Here,several reasons for the delayed onset of action and the progress in the development of early-onset antidepressants are reviewed.
