Progression rate of MUNE at diagnosis:a prognostic factor of survival in patients with amyotrophic lateral sclerosis
- VernacularTitle:诊断时运动单位估数的线性变化率是肌萎缩侧索硬化患者生存时间的影响因素
- Author:
Xiaoxuan LIU
;
Dongsheng FAN
;
Jun ZHANG
;
Juyang ZHENG
;
Shuo ZHANG
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis;
Survival analysis;
Motor unit number estimate;
Prognosis
- From:
Journal of Peking University(Health Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the correlation between the progression rate of motor unit number estimate(MUNE) at diagnosis and survival.Methods:We included 129 patents with amyotrophic lateral sclerosis(ALS) enrolled in our hospital from January 2002 to December 2005.We recorded clinical features,ALS functional rating scale(ALSFRS),forced vital capacity(FVC) and electrophysiological data at diagnosis.The patients were monitored every 3 months from visit to death or tracheotomy.Results:Mean age at onset was(52.19?11.00) years.The median survival time from symptom onset was 45.71 months(95% CI = 35 to 51).In univariate analysis of Kaplan-Meier method,outcome was significantly related to progression rate of MUNE(P
