Effect of Arginine Vasopressin V_1 Receptor Antagonist on Oxotremoreine-induced Hypothermic Responses in the Rat
- VernacularTitle:精氨酸加压素V_1受体阻断剂对氧化震颤素引起低温反应的影响
- Author:
Yan LAI
;
Yonglu YANG
;
Ziling SHEN
;
Tao HUANG
;
Jia REN
- Publication Type:Journal Article
- Keywords:
Oxotremorine;
Hypothermic response;
Arginine vasopressin V1 antagonist
- From:
Journal of Medical Research
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Study wheather the endogenous arginine vasopressin(AVP)is involved in the effect of oxotremorine(a muscarinic receptor agonist)-induced hypothermic response.Methods Core temperature and motor activity were monitored in undisturbed rats using radiotelemetry.Effect of AVP V1 antagonist on oxotremorine(OXO)-induced changes in body temperature and motor activity were observed in the rats.Results Administration of OXO led to a marked hypothermia.Core temperature recovered to basal levels at 4 hours after OXO administration.AVP V1 antagonist blocked markedly the hypothermia effect of OXO.Conclusion The AVP V1-receptor antagonist block the hypothermic effect of OXO,which suggests that OXO-induced hypothermia is mediated by AVP releasing.
