EphA2/EphrinA1 expressions in human gastric carcinoma and their relationship with angiogenesis
- VernacularTitle:EphA2/EphrinA1在胃癌组织中的表达及与血管生成的关系
- Author:
Hui LIU
;
Jianwen GUO
;
Jianghui LIU
;
Lianfu ZUO
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
EphA2;
EphrinA1;
angiogenesis;
immunohistochemistry
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of EphA2 and its ligand EphrinA1 and their relationship with angiogenesis in gastric carcinoma. Methods Expressions of EphA2,EphrinA1 and CD34-stained microvessel density (MVD) were detected by immunohistochemical assay in gastric carcinoma tissues,adjacent tissues (1.5 to 2 cm from the mass) and normal gastric mucosa (5 to 10 cm from the mass) from 82 cases. The correlations among EphA2 and EphrinA1 expressions,MVD and clinic pathological features were analyzed. Results EphA2,EphrinA1 expressions and MVD in gastric carcinomas tissues were significantly higher than those in adjacent tissues and normal gastric tissues (P
