Antioxidants protects against peripheral nerve damages induced by antiepileptic drugs in rats
- VernacularTitle:抗氧化剂防治抗癫痫药所致周围神经损伤的实验性研究
- Author:
Min ZHONG
;
Fangcheng CAI
;
Xiaoping ZHANG
;
Yan SONG
- Publication Type:Journal Article
- Keywords:
antiepileptic drugs;
peripheral nerves;
antioxidants;
oxidative stress
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective efficacy of antioxidants (vitamin E and Ginkgo biloba extract) on the peripheral nerve damages induced by antiepileptic drugs (AEDs). Methods Adult (2-month old) and infant SD rats (7-day old) were respectively treated with AEDs (phenytoin,or phenobarbital,or clonazepam) alone,or simultaneously with vitamin E or Ginkgo biloba extract for 4 weeks. All the rats were sacrificed,sciatic nerves and serum were collected. The sciatic nerves were analyzed by histologically for their pathological changes,and serum and homogenate of sciatic nerves were investigated for their total antioxidative capacity and antioxidant enzyme activity. Results Incidence of pathological abnormalities of teased fibers significantly reduced in all rats treated with AEDs and antioxidants (P
