Study on proteome of angina blood stasis syndrome by 2D-difference gel electrophoresis and mass spectrometry
- VernacularTitle:差异凝胶电泳技术寻找冠心病心绞痛血瘀证的相关蛋白
- Author:
Huihui ZHAO
;
Shuzhen GUO
;
Na HOU
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Unstable angina;
Blood stasis syndrome;
Plasma;
Proteomics;
Two-dimensional di erence gel electrophoresis;
Biomarker
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To seek differentially expressed plasma proteins of unstable angina blood-stasis syndrome.Methods:2-dimensional di rence gel electrophoresis and mass spectrometry were used to screen the di erentially expressed plasma proteins among unstable angina blood-stasis syndrome and healthy volunteers.Results:Compared with healthy people,the express of Clusterin,ApoA-I of unstable angina blood-stasis syndrome patient decreased while the expression of Fibrinogen ? chain,Vitamin D-Binding Protein,Haptoglobin ? chain,Haptoglobin ?2 chain increased.Conclusion:Fibrinogen ? chain,Fibrinogen ? chain,Haptoglobin ? chain,Haptoglobin ?2 chain,Clusterin,ApoA-I may be correlative with blood-stasis syndrome.
