Clinical research of tetramethylpyrazine for treating severe acute pancreatitis
10.3969/j.issn.1671-8348.2014.03.010
- VernacularTitle:川芎嗪治疗胰腺相关性肺损伤临床疗效研究
- Author:
Lan ZHOU
;
Fachun ZHOU
- Publication Type:Journal Article
- Keywords:
pancreatitis,acute necrotizing;
respiratory distress syndrome,adult;
tetramethylpyrazine
- From:
Chongqing Medicine
2014;(3):283-284,287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether the early use of tetramethylpyrazine(TMP) could improve the oxygenation ,reduce the rate of pulmonary lesion ,increase the survival rate and shorten the hospital days in the patients with severe acute pancreatitis (SAP) .Methods A total of 42 patients with SAP were randomly divided into the control (C) group(21 cases ,receiving the conven-tional treatment combined with the respiratory support treatment ) .The TMP group(21 cases ,receing the conventional treatment , respiratory support and TMP treatment ) .Results In the C group ,6 cases were intubated(28 .57% ) ,9 cases were acute respiratory distress syndrome(ARDS)(42 .86% ) ,the survival rate was 80 .95% ,the average hospitalization was (21 .6 ± 7 .3)d;in the TMP group ,3 cases were intubated(14 .28% ) ,6 cases were ARDS(28 .57% ) ,the survival rate was 85 .71% ,the average hospitalization was(17 .9 ± 6 .4)d .The survival rate had no statistical difference between the two groups (P>0 .05) .In addition ,the TMP group was superior to the C group in the average hospital days .Conclusion Eerly TMP interrention significantly reduced the rate of endo-tracheal intubation and the occurrence rate of ARDS ,shorten the hospital days ,but without increasing the survival rate .
