Mixed Large Cell Neuroendocrine Tumor and Adenocarcinoma of the Ovary.
- Author:
Wonjeong YOO
1
;
Noh Hyun PARK
;
Hoenil JO
;
Soo Jin CHAE
;
Hye Sil SEOL
;
In Ae PARK
;
Jae Weon KIM
;
Yong Sang SONG
;
Soon Beom KANG
;
Hyo Pyo LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. pnhkhr@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Large cell neuroendocrine tumor;
Ovarian adenocarcinoma
- MeSH:
Adenocarcinoma*;
Carboplatin;
Carcinoma, Neuroendocrine;
Diagnosis;
Drug Therapy, Combination;
Female;
Humans;
Laparotomy;
Middle Aged;
Mucins;
Neuroendocrine Cells;
Neuroendocrine Tumors*;
Ovarian Neoplasms;
Ovary*;
Paclitaxel;
Peritoneal Cavity
- From:Korean Journal of Obstetrics and Gynecology
2006;49(9):1999-2003
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neuroendocrine tumor is a very heterogenous group arising from the neuroendocrine cells. Especially, large cell neuroendocrine tumor of the ovary is a extremely rare aggressive neoplasm, characteristically arising in association with a surface epithelial tumor. This report describes a mixed type of large cell neuroendocrine carcinoma and adenocarcinoma of the ovary. A 63-year old woman presented with abdominal distension and discomfort underwent staging laparotomy under the impression of ovarian cancer. The operation revealed an small ovarian mass with invasion of multiple region in peritoneal cavity by the tumor. Immunohistochemical and ultrastructural analysis confirmed the neuroendocrine nature of the tumor. The adenocarcinoma in this case is mixture of mucinous and endometrioid type. A diagnosis of stage IIIc mixed large cell neuroendocrine tumor and adenocarcinoma of the ovary was rendered. She is subsequently being treated with Paclitaxel and Carboplatin combination chemotherapy.
