Relationship of VEGF-D and uPA with invasion and metastasis of human colon carcinoma
- VernacularTitle:结肠癌中VEGF-D和uPA的表达与侵袭转移的关系
- Author:
Zhulin LI
;
Mingcai ZHU
;
Pujiang DONG
- Publication Type:Journal Article
- Keywords:
colonic neoplasms;
vascular endothelial growth factor D;
urokinase-type plasminogen activator;
metastasis
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of endothelial growth factor-D (VEGF-D) and urokinase-type plasminogen activator (uPA) in colon carcinoma and to reveal their correlation with the tumor invasion and metastasis. Methods The expressions of VEGF-D and uPA were detected by immunohistochemistry and Western blotting in 30 specimens of colon carcinoma and 30 specimens of normal neighbouring colon tissue 5 cm away from the lesions. Results The expressions of VEGF-D and uPA mostly located in endochylema, less in nucleus, of both tumor tissue and normal tissue, and they were significantly higher in tumor tissue than normal tissue (P
