Renoprotective effect of simvastatin on adriamycin-induced nephropathy in rats
- VernacularTitle:辛伐他汀对阿霉素肾病大鼠的治疗作用及白细胞介素-1?表达的影响
- Author:
Wei ZHANG
;
Qiu LI
;
Lijia WANG
;
Xiqiang YANG
- Publication Type:Journal Article
- Keywords:
nephropathy;
glomerulosclerosis;
HMG-CoA reductase inhibitor;
interleukin-1 beta
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of interleukin-1 beta (IL-1?) in glomerulosclerosis secondary to adriamycin (ADR)-induced nephropathy in rats, and the effect of simvastatin on the expression of IL-1?. Methods Male Sprague-Dawley rats were randomly divided into normal control, ADR-induced nephropathy (model), and simvastatin-treated ADR nephropathy (treatment) groups. After ADR-induced nephropathy establishment in model and treatment groups, and eleven weeks of intragastrical administer of normal saline in normal control and model groups and of simvastatin in treatment group, the expression of IL-1? was detected by immunohistochemistry, RT-PCR and ELISA. Histopathological change of renal tissues was observed under light microscope, and glomerulosclerosis index (GSI) was also evaluated. Results Higher expression of IL-1? in kidney and GSI, as well as more severe loss of renal function were observed in model group than those in control group (all P
