Quality control study on Bidouyan mixture
10.3760/cma.j.issn.1008-6706.2013.17.002
- VernacularTitle:鼻窦炎合剂的质量控制研究
- Author:
Yingping CHEN
;
Xia ZHANG
- Publication Type:Journal Article
- Keywords:
Bidouyan mixture;
Ephedrine hydrochloride;
Chromatography,high performance liquid chromatography;
Quality control
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(17):2563-2565,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application of HPLC method in the determination of contents of ephedrine hydrochloride in Bidouyan mixture.Methods A HPLC method detected by one wavelength-210 nm for ephedrine hydrochloride had been developed.The chromatographic procedure for determination was carried out using DiamonsilTM C 18 (250mm x 4.6mm,5 μm) as an analytic column gradient eluted with a mixture consisting of acetonitrile and 0.05％ H3PO4.Results The ranges of calibration curve of ephedrine hydrochloride was 0.011 ～ 0.277mg/ml.The established HPLC method was applied to determine 15 samples of Bidouyan mixture.The results showed that the ranges of ephedrine hydrochloride was 0.10 ～ 0.23mg/ml.Conclusion A simple,effective and feasible HPLC method to determine the contents of ephedrine hydrochloride was established for the quality control of Bidouyan mixture.
