The research progress of the computer simulation technology of three-dimension structure of human N-acetyltransferase2 protein
- VernacularTitle:人类N-乙酰化酶2蛋白质三维结构的计算机模拟技术的研究进展
- Author:
Zhiyuan ZHU
;
Jing YUAN
;
Jinheng LI
- Publication Type:Journal Article
- Keywords:
N-acetyltransferase 2;
three-dimension structure of the protein;
structure simulation
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
N-acetyltransferase 2 is an important metabolic enzyme in the human body,participating mainly in the metabolism of medicine containing nitrogen.Presently a lot of researches have been undertaken in the respects like the determination of NAT2 genotype and drug metabolism and so on.In the recent years,more and more attention is paid to the simulation of three-dimension(solid)structure of protein,but the study is just at the outset on three-dimension structure of the NAT2 as well as its structure-function relationship when combined with drug.The research progress of construction of the three-dimension structure of NAT2 is summarized,emphasizing on its methods and tools.
