Interactions of anticancer drugs and miRNA targets
- VernacularTitle:抗肿瘤药物与miRNA靶点相互作用研究进展
- Author:
Jiajie ZHANG
;
Guangfa WANG
;
Shuguang WU
- Publication Type:Journal Article
- Keywords:
miRNA;
anticancer drug;
chemosensitivity;
drug target;
tumor cell
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
miRNA are large class of small noncoding RNAs that play important roles in the development of various diseases such as cancers.This review summarizes the miRNA biogenesis and related enzymes or cofactors,the alteration of miRNA expression induced by antitumor drugs as well as the interaction of these drugs and miRNA.The paper also predicts the future research aspects for miRNA,including the functional studies of miRNAs,the drug screening based on miRNA and the regulatory mechanisms of miRNA expression by drugs.
