The inhibitory effect of dexamethasone on the expression of SH2-B? protein in a murine model of asthma
- VernacularTitle:地塞米松抑制哮喘小鼠SH2-B?蛋白表达
- Author:
Jinping QI
;
Qiaoling WANG
;
Yun JIN
;
Ying HU
- Publication Type:Journal Article
- Keywords:
SH2-B?;
dexamethasone;
lung;
spinal ganglia;
spinal cord;
asthma;
mice
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the inhibitory effect of dexamethasone on the expression of SH2-B? in the lung and the visceral sensory afferent system(C7-T5 spinal ganglia and the corresponding posterior horn of the spinal cord)of asthmatic mice.Methods Murine model of asthma of BABL/c mice was induced by ovalbumin in vivo.By means of immunohistochemistry and Western blot,the expression of SH2-B? in the lung,C7-T5 spinal ganglia and corresponding spinal cord was detected and the inhibitory effect of dexamethasone on it was observed.Inspiratory airway resistance was measured with AniRes 2003 lung function system.Results The expression of SH2-B? in the lung,C7-T5 spinal ganglia and the corresponding spinal cord of the asthmatic mice was much higher than that of the control group and the dexamethasone group(P
