Study of the Regulation Effects of Oridonin on Pulmonary Artery Pressure in Pulmonary Hypertension Rats with Chronic Hypoxia-hypercapnia and Its Mechanism
- VernacularTitle:冬凌草甲素对低氧高二氧化碳肺动脉高压大鼠肺动脉压的调控作用及机制研究
- Author:
Yu SUN
- Publication Type:Journal Article
- Keywords:
Oridonin;
hypoxia;
hypercapnia;
apoptosis;
mitochondria
- From:
Journal of Zhejiang Chinese Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study the regulation effects of Oridonin on pulmonary artery pressure in pulmonary hypertension rats with hypoxia-hypercapnia and its mechanism.[Methods]SD rats were divided in to three groups randomly: the normal control group(NC),the hypoxia-hpercapnia group(HH),and the hypoxia-hpercapnia plus Oridonin group(O).The time of hypoxia-hypercapnia was 4 weeks.The mean pulmonary artery pressure(mPAP),right ventricular rate(RV/(LV+S)),percentage of thickness of pulmonary artery wall in vascular external diameter(WT%),percentage of pulmonary artery wall area in total vascular area(WA%),vitality of caspase3 and caspase9,expression cyt-c of each group were observed.[Results]The mPAP,RV/(LV+S),WT%,WA% in group HH were significantly higher than those in group NC(P
