Experimental Study on Effect of Homoharringtonine on SP,IL-1? and TNF-? in Rats of Adjuvant Arthritis
- VernacularTitle:高三尖杉酯碱对大鼠佐剂性关节炎SP及IL-1?、TNF-?影响的实验研究
- Author:
Hongde FENG
;
Haiying KANG
;
Xinwei SONG
- Publication Type:Journal Article
- Keywords:
Homoharringtonine;
Adjuvant Arthritis Rats;
SP;
IL-1?;
TNF-?
- From:
Journal of Zhejiang Chinese Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe the effect of Homoharringtonine on Adjuvant Arthritis Rats.[Methods]Observe the effect of Homoharringtonine on Adjuvant Arthritis Rats’ SP,IL-1? and TNF-?;we take the Adjuvant Arthritis Rats as model and Tripterygium wilfordii polycoside was the positive group.[Results]The Homoharringtonine and Tripterygium wilfordii polycoside group’s level of TNF-?,IL-1? in the serum and synovial membrane decreased instructively,and their dose of SP in the plasma and synovial membrane was suppressed obviously too.[Conclusion]Homoharringtonine has the effect of anti-inflammation,it may treat the Adjuvant Arthritis Rats through reducing the dose of TNF-?,IL-1? in the serum and synovial membrane,inhibiting the secretion and releasing SP in the plasma and synovial membrane.
