Variances of the Gene Expression in Adipose Tissue of NAFLD Rats Intervened with the Compound of Polygonum Caspidatum
- VernacularTitle:虎杖复方对非酒精性脂肪肝大鼠的干预与脂肪组织相关基因表达的变化
- Author:
Qinglan JIANG
;
Jun MA
;
Jinyao PAN
;
Yuyuan LI
;
Xiuxia LEI
- Publication Type:Journal Article
- Keywords:
Non-alcoholic fatty liver disease;
Polygonum caspidatum;
Leptin;
Adiponectin;
Tumor necrosis factor ?;
Uncoupling protein 2;
Resistin
- From:
Journal of Medical Research
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the intervened effect of the compound of Polygonum caspidatum to the NAFLD rat models and analyze its mechanism at the level of gene expression.Methods The Wistar rats were fed with high fatty chow to induce NAFLD and intervened with the compound of Polygonum caspidatum.The mRNA relative level of leptin,adiponectin,tumor necrosis factor ?,resistin and uncoupling protein 2 in the adipose tissue of the intervenient and control rats was detected with RT- qPCR method.The data differences between two groups were analyzed in t-test.Results Comparing to the control group,the relative level of leptin mRNA in the intervenient group was significantly increased(P0.05).At the same time,the resistin and UCP2 mRNA didn’t been detected in all samples of these two groups.Conclusion Metformin hydrychloride can adjust the adipose metabolism in liver and improve the steatosis and inflammatory reaction in liver cell.
