The Effect of NO-1886 on the Expression of Protein Kinase C in the Kidneys of Diabetic Minipig Model Induced by High-sucrose and High-fat Diet
- VernacularTitle:NO-1886对高糖高脂喂养小型猪肾脏蛋白激酶C表达的影响
- Author:
Tianshu GAO
;
Yi LIU
;
Hongguang LI
;
Xiuhong ZU
;
Weidong YIN
;
Zongbao WANG
- Publication Type:Journal Article
- Keywords:
NO-1886;
DN;
PKC
- From:
Journal of Medical Research
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective the effect of NO-1886 on the expression of protein kinase C in the kidneys of diabetic minipig model induced by high-sucrose and high-fat diet.Methods 15 Guangzhou minipigs aged 3 months were randomly divided into 3 groups of normal control,diabetes,diabbetes treatment,which were fed by basaldiet,high sucrose and high fat feed or with 1.0%No-1886 respectively.These minipigs were killed at the end of 5th month.Minipigs fed with high fat/high sucrose diet were treated with No-1886,and The fasting concentrations of plasma glucose,triglyceride,serum insulin and PKC were observed.Results High fat high sucrose feeding elevated fasting plasma glucose,trglyceride and serum insulin levels significantly.Supplement of No-1886 into high fat high sucrose diet induced a decrease in plasma glucose,triglyceride,insulin and PKC concentration compared with pigs fed with the sole high fat high sucrose diet.Conclusion No-1886 suppressed plasma glucose,triglyceride,insulin and PKC level.
