The Effects of Unaggregated Amyloid ? Protein(25-35) on Transient Outward Potassium Current in Rat Hippocampal CA3 Pyramidal Neurons
- VernacularTitle:非凝聚态淀粉样蛋白对大鼠海马神经元瞬时外向钾电流的影响
- Author:
Lin LI
;
Zhenzhai LIU
;
Bingjun HE
;
Yu QI
- Publication Type:Journal Article
- Keywords:
AD;
Unaggregated A?_(25～35);
Transient outward potassium channel(I_A);
Hippocampal CA3 pyramidal neuron
- From:
Journal of Medical Research
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of unaggregated amyloid ? protein(A?25～35) on transient outward potassium channel(IA) in Rat Hippocampal CA3 Pyramidal Neurons.Methods Patch-clamp technique with whole cell recording was used.Results Unaggregated A?25～35 inhibited IA in neonatal rat hippocampal CA3 pyramidal neurons and displayed a time-,concentration- and voltage-dependent manner;the dynamic characteristics of IA were influenced:shifted the steady-state activation and inactivation curves to left significantly.Conclusion These results suggest that the inhibition of unaggregated A?25-35 on transient outward potassium channel in acutely isolated hippocampal CA3 pyramidal neurons may be an important mechanism of its toxicity,which participates in pathological changes of AD.
