Effect of Continuous Blood Purification on Endotoxin Receptor and Signal Transduction of Patients with Multiple Organ Dysfunction Syndrome
- VernacularTitle:连续血液净化对MODS患者内毒素受体及其信号传导的影响
- Author:
Jiandong LIN
;
Xiongjian XIAO
;
Bide WU
;
Yon LIU
- Publication Type:Journal Article
- Keywords:
Continuous blood purification(CBP);
Multiple organ dysfunction syndrome(MODS);
Endotoxin receptor;
Signal transduction
- From:
Journal of Medical Research
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effct of continuous blood purification(CBP)on endotoxin receptor and signal transduction of patients with multiple organ dysfunction syndrome(MODS).Methods Thirty patients with MODS were selected and treated with low volume and high volume haemofiltration.Plasma level of TNF-?、IL-6 were messured before and after CBP at 6h,1d,3d.Express of PMN CD14mRNA,CD14 protein and activity of NF-?B were also observed.Results CBP had no effect on TNF-?,and plasma IL-6 decreased significantly(P
