Effects of adrenalectomy on innate immune responses in rats following blast injury
- VernacularTitle:肾上腺切除大鼠冲击伤后天然免疫功能的变化及其与模式识别受体的关系
- Author:
Ce YANG
;
Linlin ZHOU
;
Jun YAN
;
Haiyan WANG
;
Jianyun ZHOU
;
Qing LIU
;
Ying CHEN
;
Li CUI
;
Jianxin JIANG
- Publication Type:Journal Article
- Keywords:
trauma;
neuroendocrine response;
innate immune;
adrenalectomy
- From:Journal of Third Military Medical University
2003;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The regulation of neuroendocrine hormones on the innate immune responses remains controversial.This report investigated whether the adrenal-derived hormones directly enhanced the innate immune responses and alternation of main pattern recognition receptors in adrenalectomized rats following blast injury.Methods Bilateral adrenalectomy was performed on Sprague-Dawley adult rats,who inflicted with mild blast wave injury in 7 d later.Peripheral blood leukocyte counting,macrophage phagocytosis,bacterial translocation(BT) in lungs,livers and mesenteric lymph nodes(MLN) were measured and analyzed,and TNF-? level in the lung tissue was detected.The mRNA expressions of scavenger receptor-A(SR-A),CD14 and Toll like receptor-4(TLR-4) were assessed with RT-PCR.Results After blast injury,the number of peripheral leukocytes was decreased(P
