The effect of the preoperative oral carbohydrate treatment on immediate postoperative insulin resistance in patients after colorectal cancer resection
- VernacularTitle:术前口服糖类溶液对结肠癌病人术后即时胰岛素抵抗的影响
- Author:
Zhiguo WANG
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
Carbohydrate;
Insulin resistance;
Colorectal tumorectomy;
Elective operation
- From:
Parenteral & Enteral Nutrition
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the effect of preoperative carbohydrate fluid intake on immediate postoperative insulin resistance. Methods: 32 patients for elective colorectal cancer resection were recruited to this randomized controlled study. These patients were randomly assigned to control group and test group. Control group were fasted before surgery, while test group were given oral carbohydrate 3 h before surgery. Patient's wellbeing scores on a visual analogue scale(VAS) were recorded at 3 PM the day before operation and 2 h after consuming carbohydrate fluid respectively. Blood sample were collected to measure the level of blood glucose and the serum concentrations of insulin 4 h before surgery and immediately after surgery, respectively. Homeostasis model assessment (HOMA) was applied to assess the status of insulin resistance (HOMA-IR), basic function of pancreatic ? cell (HOMA-? cell) and insulin sensitivity index (ISI). Results: Patients consumed carbohydrate-rich beverage before surgery reduced thirst, hunger and anxiety compared with fasting before surgery. Whole body insulin sensitivity decreased by 33% in the test group vs. 38% in the control group(P
