Effect of Shengmai capsules on MMP-3&TIMP-1 of cardiac muscle in rats with chronic congestive heart failure
- VernacularTitle:生脉胶囊对慢性心力衰竭大鼠心肌MMP-3与TIMP-1的影响
- Author:
Yuanjiang DENG
;
Weixiong LIANG
;
Weiying LIU
;
Shuyi CHENG
;
Yunbo CHEN
- Publication Type:Journal Article
- Keywords:
Congestive Heart Failure(CHF);
Matrix Metalloproteinase(MMPs);
Tissue Inhibitor of Metalloproteinase (TIMPs);
Ventricular Remodeling;
Shengmai capsules
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research the effect of Shengmai capsules on the matrix metalloproteinase(MMPs)& tissue inhibitor of metalloproteinase(TIMPs)in chronic congestive heart failure(CHF)rats.Methods:75 SD female rats weredivided randomly into 5 groups:sham-operation group(A),CHF model group(B),CHF model treated by Shengmai capsules group(Shengmai capsule group,C),CHF model treated by Captopril group(Captopril group,D),CHF model treated by Shengmai capsule and Captopril group(shengmai capsule&captopril group,E),15 rats each group.Suprarenal abdominal artery constriction was operated to prepare CHF rat models.After 7 week treating respectively,the contents of MMP-3&TIMP-1 of cardiac muscle in rats were detected.Results:The content of cardiac MMP-3 was higher in group B than in group A(P
