Study on effect of benefiting qi and activating blood formula on AngⅡ,PKC in myocardial tissue of rats with chronic heart failure
- VernacularTitle:益气活血复方对慢性心衰大鼠心肌组织AngⅡ及PKC的影响
- Author:
Yan ZHANG
;
Shuo YANG
;
Min PANG
;
Tingting SONG
;
Xiaohong HU
;
Hai LI
- Publication Type:Journal Article
- Keywords:
Chronic heart failure;
Benefiting qi and activating blood formula;
AngⅡ;
PKC
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explain the mechanism of benefiting qi and activating blood formula on chronic heart failure (CHF)by observing the signal transduction through the medium of AngⅡ,PKC in rat myocardium.Methods:Healthy male SD rats were selected and CHF model were made by ligation of coronary artery combined with starvation and exhausted swimming. Successful model rats were randomly divided into 4 groups:model group,Chinese medicine high dose group,Chinese medicine middle dose group,west medicine control group,each group with 8 rats.In addition,normal control group was set.After 8 weeks, the content of AngII,PKC in myocardial tissue was tested by ABC immunohistochemical method,and the ultrastructural changes of myocardial cell were observed with transmission electronic microscopy.Results:Compared with normal control group,heart function decreased obviously(P
