Analysis of the Potent Prognostic Factors in Luminal-Type Breast Cancer.
10.4048/jbc.2012.15.4.401
- Author:
Han Sung KIM
1
;
Inseok PARK
;
Hyun Jin CHO
;
Geumhee GWAK
;
Keunho YANG
;
Byung Noe BAE
;
Ki Whan KIM
;
Sehwan HAN
;
Hong Joo KIM
;
Young Duck KIM
Author Information
1. Department of Surgery, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. s2606@inje.ac.kr
- Publication Type:Original Article
- Keywords:
Bcl-2;
Breast neoplasms;
Prognosis
- MeSH:
Breast;
Breast Neoplasms;
Disease-Free Survival;
Estrogens;
Humans;
Lymph Nodes;
Medical Records;
Multivariate Analysis;
Neoplasm Metastasis;
Phenobarbital;
Prognosis;
Receptor, Epidermal Growth Factor;
Receptor, erbB-2;
Receptors, Progesterone
- From:Journal of Breast Cancer
2012;15(4):401-406
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Luminal-type breast cancer has a good prognosis compared to other types, such as human epidermal growth factor receptor 2 and triple negative types. Luminal-type breast cancer is classified into luminal A and B, according to the proliferation index. We investigated the clinicopathological factors that affect the prognosis of the luminal-type subgroups. METHODS: We reviewed the medical records and the pathologic reports of 159 luminal-type breast cancer patients who were treated between February 2005 and November 2007. We divided luminal-type breast cancer into luminal A and B, according to Ki-67 (cutoff value, 14%) and analyzed the clinicopathologic factors, such as age at diagnosis, intensity score of estrogen receptor and progesterone receptor, histologic grade, and Bcl-2. Moreover, we compared the disease-free survival (DFS) of each group. RESULTS: In the univariate analysis, age (p=0.004), tumor size (p=0.010), lymph node metastasis (p=0.001), and Bcl-2 (p=0.002) were statistically significant factors in luminal-type breast cancer. In the multivariate analysis, lymph node (p=0.049) and Bcl-2 (p=0.034) were significant relevant factors in luminal-type breast cancer. In the subgroup analysis, the increased Bcl-2 (cutoff value, 33%) was related with a longer DFS in the luminal B group (p=0.004). CONCLUSION: In our study, luminal A breast cancer showed a longer DFS than luminal B breast cancer, further, Bcl-2 may be a potent prognostic factor in luminal-type breast cancer.
