Research progress of the anti-hepatitis virus mechanism of interferon-alpha and long-acting form of interferons
- VernacularTitle:干扰素-?及长效干扰素抗肝炎病毒作用机制的研究进展
- Author:
Bingfa XU
;
Qinglin FAN
;
Wei WEI
;
Lihua SONG
- Publication Type:Journal Article
- Keywords:
interferon-alpha;
long-acting interferon;
hepatitis B virus;
hepatitis C virus;
signal transduction
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Interferon-alpha is one of the most important drugs against hepatitis virus,and it can inhibit the replication of virus by inducing the expression of 2'-5'-OAS,PKR,MxA through Jak-STAT pathway in hepatocytes.The effects are also concerned with other signal pathways,such as MAPK,IRS-1/PI3K-p70S6 kinase pathways and so on.In order to prolong the half life of interferon-alpha and enhance its effectiveness,many other long-lasting interferons are developed,such as pegylated interferon,recombinant human serum albumin-interferon,and liposome interferon,which maybe take the place of interferon-alpha.The research and development of more long-acting and efficient interferons are becoming a more and more important way to the anti-virus treatment of hepatitis.
