Protective effects of M_3 receptor agonists on the arrhythmias of rats induced by barium chloride
- VernacularTitle:M_3受体激动剂对氯化钡诱发大鼠心律失常的保护作用
- Author:
Danlu LI
;
Liyan WANG
;
Lipeng CHEN
;
Xiuju ZHANG
;
Yan LIU
;
Baofeng YANG
- Publication Type:Journal Article
- Keywords:
M3 receptor agonist;
choline;
pilocarpine;
4-DAMP;
barium chloride;
arrhythmia
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the protective effects of choline and pilocarpine,the M3 receptor agonists,on the arrhythmias of Wistar rats induced by barium chloride.Methods Barium chloride was used to induce the experimental arrhythmias of Wistar rats.Choline,pilocarpine,and 4-diphenylacetoxy-N-methylpiperidine-methiodide (4-DAMP),the selective antagonist of M3 receptor,were used to explore the effects of M3 receptor on the arrhythmias induced by barium chloride.The occurence and the severity of arrhythmias were observed.Results Choline 10 mg?kg-1 and pilocarpine 0.2 mg?kg-1 inhibited the occurence of arrhythmias,shortened the duration of arrhythmias (P
