Expression of neuroglobin after focal cerebral ischemia and its neuroprotective effect
- VernacularTitle:脑红蛋白在脑缺血大鼠中的动态表达及脑保护作用
- Author:
Jing YIN
;
Xiangjian ZHANG
;
Litao LI
;
Yi YANG
- Publication Type:Journal Article
- Keywords:
middle cerebral artery infarction;
hemorrhagic infarction;
Hemin;
neuroglobin
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of neuroglobin (Ngb) in rat cerebral ischemia model and the neuroprotective effect of Ngb after ischemia and hypoxia. Methods: Totally 113 Sprague-Dawley rats were randomly divided into sham-operated group, middle cerebral artery occlusion (MCAO) group, hemorrhagic infarction (HI) group and hemin treatment group. The brain water content, infarcted tissue volume, neuropathologic changes (H-E staining) and expression of Ngb (immunocytochemical staining) were examined 3, 6, 12, and 24 h after model establishment. Results: The brain water contents and the infarcted tissue volumes in the hemin treatment group were significantly different from those of the MCAO group and HI group (P
