Effects of ligustrazine on expression of HSP25 and p38MAPK proteins in rats with myocardial ischemia reperfusion injury
- VernacularTitle:川芎嗪对心肌缺血再灌注损伤大鼠HSP25和p38MAPK表达的影响
- Author:
Lizhi SHANG
;
Dawen WEI
;
Feng WANG
- Publication Type:Journal Article
- Keywords:
Ligustrazine;
Ischemia reperfusion injury;
Immunohistochemistry;
HSP25;
p38MAPK
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effects and mechanism of ligustrazine on myocardial ischemia reperfusion injury(MIRI) in rats.Methods:30 Wistar rats were divided into three groups randomly:sham operation group,ischemia reperfusion injury group(IR),and ligustrazine preconditioning group(LI).The model of MIRI was produced,Immunohistochemical S-P method was used to detect the expressions of HSP25 and p38MAPK proteins in MIRI tissues.Results:Compared with IR group,the expression of HSP25 protein in LI group increased significantly(P
