Effect of total glucosides of Acantbopanax giraldii Harms on learning and memory impairment in cerebral ischemic rats
- VernacularTitle:红毛五加总苷对脑缺血大鼠学习记忆障碍的影响
- Author:
Xin WANG
;
Yang JU
;
Haisheng JIAO
;
Yuelan DANG
- Publication Type:Journal Article
- Keywords:
Total gucosides of Acanthopanax giraldii Harms;
Cerebral ischemia;
Memory impairment;
Experitmental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the intervention effect of total glucosides of Acanthopanax giraldii Harms(TGA) on learning and memory impairment and the mechanism in cerebral ischemic rats.Methods:The model of transient cerebral ischemic /reperfusion was made by bilateral occlusion of common carotid arteries in rats.Learning-memory ability was observed and the activities of superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in brain tissue were measured in rats.Results:In Ymaze test the correct reaction frequency of model group was lower than normal group(P
