Effects of dilution of blood with different amount of physiological saline in vitro on blood coagulability
- VernacularTitle:体外不同程度生理盐水稀释血液对凝血功能的影响
- Author:
Zhuoqiang WANG
;
Zhen XU
;
Xiuzhen LIU
- Publication Type:Journal Article
- Keywords:
hemodilution;
blood coagulation;
sodium chloride
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of dilution of whole blood in vitro with different amount of normal saline on blood coagulation.Methods Nineteen healthy adult volunteers were enrolled in the present study.Venous blood samples obtained from each volunteer were diluted with normal saline in saline/blood ratio(v/v) of 2∶8(20%),3∶7(30%),4∶6(40%),5∶5(50%) and 6∶4(60%).Undiluted blood was considered as control.Coagulability of each group was determined with Sonoclot coagulation and platelet function analyzer,including activated clotting time(ACT),clot rate(CR),time to peak(TP),maximal clot signal(MCS),and platelet function(PF).Results 1) ACT: Compared with control value,ACT was significantly shortened with 20% dilution(P
