Resveratrol protects against peroxide toxicity in rats induced by arsenic trioxide
- VernacularTitle:白藜芦醇减轻三氧化二砷所致大鼠过氧化毒性作用
- Author:
Zhonglu LIU
;
Yutian BI
;
Jun YUAN
- Publication Type:Journal Article
- Keywords:
arsenic trioxide;
resveratrol;
free radicals
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of resveratrol against toxicity induced by arsenic trioxide in rats.Methods Arsenic trioxide was given to SD rats intraperitoneally for 4 weeks.Resveratrol was injected intraperitoneally to the animals 4 h before arsenic trioxide challenge at dose of 30,60,or 120 mg?kg-1?d-1.Four weeks later,the contents of malondialdehyde(MDA),superoxide dismutase(SOD),nitric oxide(NO),glutathione peroxidase(GSH-Px) in serum,lung,spleen,liver and brain tissues were measured.Results Compared with the normal control rats,arsenic trioxide challenge resulted in increases of NO and MDA contents in serum,lung,spleen,liver and brain tissues,and decreases of GSH-Px and SOD levels in the rats received arsenic trioxide only.Resveratrol significantly inhibited these changes induced by arsenic trioxide in rat serum,lung,spleen,liver and brain tissues in a dose-dependent manner.Conclusion Resveratrol can protect antiperoxidase activity and inhibit peroxide productions.
